Oxandrolone (often sold under the brand name Anavar), is therapeutically used to help people gain weight. It is also used to treat bone pain in patients with osteoporosis.
Although Anavar is not a fat-loss drug, it has proven effective in helping patients retain or increase lean muscle mass. Because of this, some patients have been able to lose weight and experience greater results from workouts.
Athletes of many varieties report improvements in strength, endurance and recovery while taking this oral medication.
How Can You Benefit From Oxandrolone?
Oxandrolone is used to help you regain weight lost after surgery, severe trauma, or chronic infections. Oxandrolone is also used in people who cannot gain or maintain a healthy weight for unknown medical reasons.
What Are The Benefits of Oxandrolone?
- Decrease visceral fat and total body fat
- Increase protein synthesis in skeletal muscle
- Increase dietary energy and protein intake
- Increase nitrogen retention
- Increase muscle function, growth, strength and physical activity level
- Substitute for the natural loss of androgen and estrogen hormones
How does Oxandrolone work?
Oxandrolone increases muscle mass in three ways
1) Inducing protein synthesis in the body
2) Up regulating the androgen receptor in skeletal muscle.
3) Increasing IGF-1 (insulin-like growth factor)
Oxandrolone given to healthy men, has been shown to increase protein synthesis by as much as 44% and improve effects of resistance training.
What are the indications and usage for Oxandrolone ?
Oxandrolone can be indicated in patients chronic wasting conditions (the loss of muscle mass) to prevent frailty. Such conditions include sarcopenia, AIDS related muscle wasting, severe burn injury, trauma following surgery and other catabolic disorders.
Anavar is approved by the FDA for the treatment of patients with prolonged use of corticosteroids to prevent protein catabolism and has been used to promote weight gain after extensive surgery, during chronic infectious states, or after severe trauma.
How is Oxandrolone absorbed?
Oxandrolone is an oral medication that is absorbed across the gastrointestinal tract. Peak serum concentrations of Anavar occur within 1 hour after ingestion. In the body, Anavar is 95% bound to protein, which may contribute to the steroid’s stability and resistance to breakdown by the liver.
How is Oxandrolone metabolized (broken down)?
Unlike other hormones, oxandrolone is rather resistant to liver biotransformation. Approximately 28% of Anavar is excreted in the urine unchanged.
What is the difference between Testosterone and Oxandrolone ?
Oxandrolone has a much higher potential to promote anabolic effects on the human body such as an increase muscle size, strength, nitrogen retention, reduce fat deposition and induce protein synthesis compared to testosterone.
While testosterone will also promote androgenic affects, Anavar was designed to lessen the unwanted androgenic effects and promote more anabolic properties.
Oxandrolone has much higher anabolic activity compared to testosterone. Oxandrolone has an anabolic: androgenic ratio of 10:1 and a higher steroid protein activity level (SPAI) of 2.8. Testosterone on the other hand has an anabolic: androgenic ration of 1:1 and an SPAI of 1.
How does using Oxandrolone (Anavar) effect Testosterone production?
Oxandrolone usage will decrease the natural pituitary axis necessary to maintain testosterone production. Men who use Anavar will experience a decrease in LH, FSH, SHBG and total and free testosterone.
More commonly in men with chronic muscle wasting conditions or HIV wasting, Anavar is combined with testosterone.
Oxandrolone usage has been shown to reduce sex hormone binding globulin (SHBG). Reduction in SHBG reduction increases the amount of free testosterone (active) in the body.